Name: Pan Xiaohua

Academic qualifications:

  • 1987-1993: B. Med. Medicine College(six years schooling system)of Sun yat-sen university, Guangzhou, China.
  • 2002-2005: M. Med. Medicine College(three years schooling system) of Jinan University, Guangzhou, China.
  • 2006-2009: M.D. &PH.D. TongJi Medicine College(three years schooling system) of Huazhong University of Science and Technology, Wuhan, China.
  • 2009-2012: Postdoctoral Research Fellow & Academic Visitor Scholar (Honour Associated Professor). Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong. (CUHK). Hong Kong
Professional qualifications:
  • 1993-1998: Resident surgeon. Department of Orthopaedics & Traumatology, Shenzhen People¡¯s Hospital, Second Medical College of Ji'nan University,Shenzhen, China
  • 1998-2004:Attending Orthopedic surgeon. Department of Orthopaedics & Traumatology, Shenzhen People¡¯s Hospital, Second Medical College of Ji'nan University,Shenzhen, China
  • 2004-2008 Associated Orthopedic surgeon. Department of Orthopaedics & Traumatology, Shenzhen People¡¯s Hospital, Second Medical College of Ji'nan University,Shenzhen, China
  • 2008-2012:Chief Orthopedic surgeon. Department of Orthopaedics& Traumatology, Shenzhen People¡¯s Hospital, Second Medical College of Ji'nan University,Shenzhen, China
Acquired academic position:
  • 2007 Associated professor & Master degree candidate supervisor of Orthopaedics& Traumatology, Jinan University, Guangzhou, China
  • 2008 Membership of Emergency Medicine and Multiple Injury Committee of Chinese Traumatology Medical Association.
  • 2008 Membership of Osteoporosis Committee of Guangdong Medical Association.
  • 2009 Vice chairman of Osteoporosis Committee of Shenzhen Medical Association.
  • 2011 Corresponding editor of 3rd editorial committee of Chinese Journal of Orthopaedic Trauma.
  • 2011 Membership of Emergency Medicine and Multiple Injury Committee of Chinese Traumatology Medical Association.

Academic specialties:
  • Competent for the emergency treatment of multiple & complex trauma, fat embolism syndrome, MODS, severe shock and spinal cord injury , et al
  • Skilled for the conservative treatment of various joint dislocation, extremities fractures and the surgery treatment of external & internal fixation in extremities and pelvis fractures , et al
  • Proficient for the skills of arthroscopy and various minimally invasive techniques.
  • Expert in various artificial joint replacement.
  • Skilled for comprehensive therapy of bone tumors, osteoporosis, osteoarthritis, hereditary & congenital disease of musculoskeletal system, et al.
  • In charge of 2 NSFC Projects , as well as 6 grant by GuangDong Province and Shenzhen government technology committee (including 3 Key Projects).
  • 26 articles have been published in professional academic journals on national level.
  • 8 articles have been published SCI journals, as first author or corresponding author.
Scientific research Projects
  1. Principal investigator. Project Granted by GuangDong Government,2011.Applied research on Osteoarthritis of Knee Joint ¡ªAnalysis of Synovial Fluid of Proteome Patterns Based on iTRAQ and MALDI-TOF Mass Spectrometry(No:2011B061300092)
  2. Principal investigator. Project Granted by Shenzhen Government,2011. Quantitative study on Osteoarthritis of Knee Joint ¡ªAnalysis of Synovial Fluid of Proteome Patterns Based on iTRAQ and MALDI-TOF Mass Spectrometry(No:201101018).
  3. Principal investigator. Project Granted by Shenzhen Government,2009. The role of ER¦Â (estrogen receptor beta) gene in the repair of Postmenopausal Osteoporotic Fracture(POF)(No:200901005).
  4. Principal investigator. Project Granted by Shenzhen Government,2008. Study of therapeutic effect of Epimedium-derived Phytoestrogen Flavonoids (FE)for Osteoporotic fracture(No:200802108),completed.
  5. Principal investigator. Project Granted by Shenzhen Government,2005. Applied research of Quantitative assessment system for fracture(No:2005005),completed
  6. Principal investigator. Project Granted by Shenzhen Government,2004.Animal experiments and clinical trials of low-intensity pulsed ultrasound for fracture treatment.(No:200404036),completed
  7. Second principal investigator. Project Granted by the National Natural Science Foundation of China(NSFC),2010. Experimenalt research of acetylcholine receptor agonists GTS-21 for rheumatoid arthritis treatment.( No:81000786).
  8. Second principal investigator. Project Granted by the National Natural Science Foundation of China(NSFC),2007. Bone mesenchymal stem cell transplantation for repairing avascular necrosis of femoral head.(No:30750010), completed.
PAPERS:
  1. Ge Zhang, Baosheng Guo, Heng Wu, Tao Tang, Baoting Zhang, Lizhen Zheng, Yixin He, Zhijun Yang, Xiaohua Pan, Heelum Chow, Kinwah To, Yaping Li, Dahu Li, Xinluan Wang, Yixiang Wang, Kwongman Lee, Zhibo Hou, Nan Dong, Gang Li, Kwoksui Leung, Leungkim Hung, Fuchu He, Lingqiang Zhang, Ling Qin. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nature Medicine (Accepted SCI IF:27.136 )
  2. Pan X, Huang L, Chen J, Dai Y, Chen X.Analysis of synovial fluid in knee joint of osteoarthritis:5 proteome patterns of joint inflammation based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Int Orthop. 2011(4)21.( DOI: 10.1007/s00264-011-1258-y) (SCI IF:1.825)
  3. Xiaohua Pan, Xiaowei Yu, Ling Qin, Peng Zhang ¡®¡®Old drugs¡¯¡¯ for the treatment of rheumatoid arthritis: will the cholinergic anti-inflammatory pathway and anti-nociceptive pathway work? Inflame. Res. DOI 10.1007/s00011-010-0243-z(SCI IF: 1.586)
  4. Pan XH, Zhang J, Yu X, Qin L, Kang L, Zhang P .New therapeutic approaches for the treatment of rheumatoid arthritis may rise from the cholinergic anti-inflammatory pathway and antinociceptive pathway. ScientificWorldJournal. 2010 Nov 16;10:2248-53. (SCI IF: 1.68)
  5. PAN Xiao-hua; XIAO De-ming Study of rotating permanent magnetic field to treat steroid-induced osteonecrosis of femoral head .International Orthopedics 2009;6:617-623(SCI IF:1.825)
  6. Pan XH, Wang YG, Zhang G, Liu Z, Zeng WC, Chen JK, Dai Y, Qin L. Breeding and identification of estrogen receptor beta gene knock-out mice. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30(1):153-156.
  7. Pan Xiaohua, Zhang Ge, Qin Ling, Xiao Dengming. Epimedium-derived flavonoids exert promotion effect on osteoporotic fracture repair in postmenopausal women: Preliminary progress report until 8 weeks post fracture. Bone 2008; 43: S86 (SCI IF: 4.089)
  8. Xiaohua PAN, ShuHua YANG, Deming XIAO, Yong DAI, Lili REN.Gene expression disparity in giant cell tumor of bone. Front. Med. China.DOI 10.1007/s11684-009-0012-y
  9. Pan XH , Zhang Ge, Leung KS, Xiao DM, Qin L .Epimedium-derived flavonoids exert promotion effect on osteoporotic fracture repair in postmenopausal women: Preliminary progress report until 8 weeks post fracture. Bone (SCI IF: 4.089) 2008; 43: S86
  10. Hanratty BM, Ryaby JT, Pan XH, Li G.Thrombin related peptide TP508 promoted fracture repair in a mouse high energy fracture model. J Orthop Surg Res. 2009,29;4:1. (SCI IF:3.64)
  11. Zhang Ge, Pan Xiaohua, Xie Xinhui, He Yixin, Leung KS, Qin Ling. Icaritin, a potential estrogen receptor beta antagonist molecule Icaritin, promote osteoporotic fracture repair in ovariectomized mice: Preliminary finding at 3 Weeks post fracture. Bone 2008; 43: S76-S77 (SCI IF: 4.64)
  12. Zhang Ge, Pan Xiaohua, He Yixin, Zeng Wancheg, Xie Xinhui, Li Gang, Leung KS, Qin Ling. A highly selective estrogen receptor beta antagonist MPP dihydrochloride promotes osteoporotic fracture repair at early stage in ovariectomized mice: A preliminary finding. The Hong Kong Orthopaedic Association Annual Congress 2008C :88-89
  13. Zhang Ge, Wang Xinluan, Pan Xiaohua, Leung KS, Qin Ling. Promotion effect of Icaritin on bone formation of human periosteal cells requires antagonistic estrogen receptor beta pathway. The Hong Kong Orthopaedic Association Annual Congress 2008A:44-45
  14. PAN Xiaohua,YANG Shuhua,WU Xinghuo.Clinical effects of operative treatments for complex proximal humeral fractures of osteoporotic patients. Journal of Traumatic Surgery.2011;13(5):223-227
  15. LUO Jinghua,PAN Xiaohua(corresponding author),ZENG Wancheng,CHEN Yu.Efficacy of quantitative CT in assessment of fracture healing. Chinese Journal of Trauma.2010; 26(7):624-628
  16. LUO Jinghua,PAN Xiaohua(corresponding author),ZHANG Ge,HE Yixin,LIU Zhong,ZENG Wancheng.Experimental Research of Epimedium-derived-flavonoids for Repairing Osteoporotic Fracture.Chinese Journal of Traditional Medical Traumatology & Orthopedics.2010,18(9):10-12
  17. YE Xiyang,PAN Xiaohua(corresponding author),PANG Chunping,CHEN Dilin.An Animal Study of the Cure of Epimedium-derived Phytoestrogen Flavonoids to Osteoporosis.Journal of Hebei Normal University(Natural Science Edition). 2010,34(4):44-46
  18. PAN Xiaohua,YANG Shuhua,Wu Xinghuo.Anatomical Locking Plate Internal Fixation and Bone Grafting for the Treatment of Complex Multiple Fractures in the Extremities.Chinese Journal of Traditional Medical Traumatology & Orthopedics.2009,5(2):64-66
  19. PAN Xiaohua£¬YANG Shuhua,XIA0 Deming,CHEN Yu.Quantitative computed tomography for assessment of therapeutic efficacy of low-intensity ultrasound on distal radius fracture repair. Chinese Journal of Trauma.2008;24(7):531-535
  20. PAN Xiaohua,XIAO Deming,REN Lili,DAI Yong,LI Furong,LI Tiyuan.Gene Expression in Giant Cell Tumor of Bone by cDNA Microarray. Cancer Research on Prevention and Treatment.2008;35(2):95-99
  21. PAN Xiao-hua, XIAO De-ming, XU Zhong-shi,LIN Bo-wen,XIE Wei-ping,LI Wei-fan, et al. Clinical low-intensity pulsed ultrasound in the treatment of distal radius fracture. Chinese Journal of Physical Medicine and Rehabilitation 2006; 3:184-187
  22. PAN Xiaohua, XIAO Deming, ZHANG XiaoYun, ZHANG Yu.An experimental study of the effects of a rotating magnetic field on steroid-induced necrosis of the femoral head.Chinese Journal of Physical Medicine and Rehabilitation. 2006;28(11):735-738
  23. PAN Xiaohua, XIAO Deming, ZHANG Xiaoyun, ZHANG Yu, ZHANG Yonghong, XIE Weiping.Effect and Pathologic Mechanism of Rotating Permanent-magnetic Field to Treat Steroid-induced Necrosis of Femoral Head.Journal of Sun Yat-Sen University(Medical Sciences).2007;28(1)19-24
  24. PAN Xiaohua,HE Shuang,XIE Xiaoqing,GAN Daqiang.Combined Use of Sodium Hyaluronate and LIUS-phoresised Fastum Gel Treating Knee Osteoarthritis Complicated with Synovitis.Chinese Journal of Rehabilitation.2007; 22(2): 110 -111
  25. Pan Xiao-hua, Xiao De-ming, Lin Bo-wen, Huang Gang, et al.Dynamic hip screws (DHS) and proximal femoral nails (PFN) in treatment of intertrochanteric fractures of femur in elderly patients. Chinese Journal of Orthopaedic Trauma 2004; 7:785-794
  26. Pan Xiao-hua, Xiao De-ming, Lin Bo-wen, Huang Gang, et al. Analysis of the therapeutic effect of DCS and DFN on supracondylar fracture of femur. Hebei Medical Journal 2004; 4:306-308
  27. Wang Qingde,Yang Shuhua,Yang Cao,HU Yong£¬ZHAO Jijun£¬PAN Xiaohua.Hypoxia Inhibiting the Osteogenic Differentiation of Adult Human Mesenchymal Stem Cells in vitro.Acta Medicinae Universitatis Scientiae et Technologiae Huazhong. 2008;37,(1):55-59
  28. SONG Wei-dong,QIU Tai-bin,PAN Xiao-hua,et al.Treatment of femoral fractures combined with head injuries.Journal of Traumatic Surgery.2011;13(2): 102-105
  29. Xie Xiao-qing, Pan Xiao-hua, Li Qiao-feng, Huang Jin, et al. Treatment of the Fracture of the Tibia and Fibulia by Intramedullar Interlocking Nail. Practical Clinical Medicine 2005;2:50-51
  30. GAN Daqiang,PAN Xiaohua.Clavicular hook plate fixation in treatment of acromioclavicular joint dislocation and distal clavicular fracture.Practical Clinical Medicine.2007;8(6):81-82